“ The Hierophant of Greenmarch is a lycanthrope. Rather than seeking a cure, or hiding his condition, he considers it a blessing from the Goddess of the moon, and requires that all of the Druids and loyal Rangers of Greenmarch to share in his gift.”
“ You find a patch of edible funghi. They taste well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick with pains, vomiting, all the fancy stuff. As a gift or good meal, it could be a cruel joke or to make sure the heroes spend their time focused on the mission. And the fine soup you had in the inn yesterday could have some in.
(Inspired through a real-world fungus. Was really used to cure alcoholism.)”
“ The party comes across a nice hermit in the woods. He gives them food and lodging for the night. They awaken to his terrified screams. 'East! It's east! Stop it! It'll kill us all!' The poor horror-stricken hermit dies thrashing in agony, one boney arm outstretched, his finger pointing to the east.”