“ God has been slayed by a mortal man and his head is now worshipped and put on a pedestal. The PCs are hired to steal the head and bring it to a mystic that claims to have the power to revive God.”
“ A Deity of some sort has unleashed a plague of bookworms or something like that in the area. Almost all spellbooks are destroyed, along with bardic and historical books.”
“ After killing certain animals, if you drink their blood while performing a sort of ritual you will have visions and/or gain specific powers for an amount of time.”